By A Mystery Man Writer
This section provides comprehensive spatial profiling of the Brain, including overview of protein expression in the mammalian brain based on integration of data from human, pig and mouse. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. The data presented are for human genes and their one-to-one orthologues in pig and mouse. Gene summary pages provide the hierarchical expression landscape form 13 main regions of the brain to individual nuclei and subfields for every protein coding gene. For selected proteins, high content images are available to explore the cellular and subcellular protein distribution. In addition, the Brain section contains lists of genes with elevated expression in one or a group of regions to help the user identify unique protein expression profiles linked to physiology and function. More information about the specific content and the generation and analysis of the data in this section can be found on the Methods Summary. Learn about: Expression levels for all human proteins in regions and subregions of the human brain Expression levels for all proteins with human orthologs in regions and subregions of the pig and mouse brain Brain enriched genes with higher expression in any of the regions of the brain compared to peripheral organs Regional enriched genes with higher expression in a single or few regions of the brain Cell-type and cell-compartment distribution of selected proteins in the human and mouse brain Differences in gene expression between mammalian species Additional information: In addition to the data provided in the brain section there is also data on human retina and single cell data containing information on protein expression in human neuronal and non-neuronal cell-types in the central nervous system.
TRIM28 is highly expressed in many types of tumors (The Human
Looking back on 20 years with Human Protein Atlas
Candidate biomarkers from the integration of methylation and gene
A Human Protein Atlas for Normal and Cancer Tissues Based on
Human 'Atlas' Reveals Where Proteins Reside in the Body
Cells, Free Full-Text
HPAanalyze: an R package that facilitates the retrieval and
The Human Protein Atlas database analysis. A, B The Human Protein
Human Protein Atlas - Origins of Atlas Antibodies
Candidate biomarkers from the integration of methylation and gene
Analysis of the Human Protein Atlas Weakly Supervised Single-Cell
PDF) Fluid proteomics of CSF and serum reveal important
Study yields clues to why Alzheimer's disease damages certain
First map of all known proteins in human body is goldmine for drug