Ranking The Bulkiness Of Substituents On Cyclohexanes: A-Values

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The "steric influence" (or "bulk") of groups on a cyclohexane is quantified by measuring the equilibrium btw axial and equatorial. This is the "A-value"

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PDF) Experimental determination of the conformational free energies (A values) of fluorinated substituents in cyclohexane by dynamic 19F NMR spectroscopy. Part 1. Description of the method for the trifluoromethyl group

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Solved A-values represent the amount of energy required to

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