Drug-Like Molecules Regenerate Hair Cell-Like Cells in Adult Mice

“Think about a brake when driving a car,” Chen explains. “If the brake is always engaged, you can’t drive. We found an siRNA that could remove the brake in this genetic pathway.”

Hearing Health Foundation (HHF) is the largest non-profit funder of hearing research. Since 1958, HHF has given away millions of dollars to hearing and balance research, including work that led to cochlear implant technology and now through the Hearing Restoration Project is working on a cure for hearing loss and tinnitus. HHF also publishes Hearing Health magazine, a free consumer resource on hearing loss and related technology, research, and products.

Frontiers A Novel in vitro Model Delineating Hair Cell Regeneration and Neural Reinnervation in Adult Mouse Cochlea

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells - ScienceDirect

Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

Kyushu University succeeds in neuronal neoplasia in the inner ear of adult mice ― restoration using growth factor and valproic acid together, News

Scientists use drug-like cocktail to regenerate hair cells in preclinical study

USC Stem Cell scientists find a simpler way to make sensory hearing cells - USC Stem Cell

Frontiers Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

Highlights From the Hearing Restoration Project — Hearing Health

Renewed proliferation in adult mouse cochlea and regeneration of hair cells